Our product range includes PTFE sheet-lined equipment, PTFE spraying and roller coating, plastic-lined equipment, PTFE-lined steel pipes and fittings, and related fluoropolymer components made from PTFE, PFA, ETFE, FEP and other advanced materials.
PTFE Lined Pharmaceutical Intermediate Receiver Tank is a sanitary grade buffer receiving container independently developed for pharmaceutical purification processes, different from industrial acid storage and general process receiving vessels. This receiver tank focuses on ultra-low metal ion precipitation and easy full sterilization, specially used to collect purified medical intermediates, crystallized drug raw materials and vacuum condensed pharmaceutical distillates after reaction kettles and rectification columns. The whole tank adopts sanitary rounded corner lining design to avoid drug residue accumulation, equipped with quick-disassembly sanitary stirring and sampling interfaces, fully matching closed clean pharmaceutical production lines. It has stable delivery records to domestic and Southeast Asian GMP-certified biopharmaceutical factories.
| Parameter Item | Standard Sanitary Technical Data |
| Full Name | PTFE Lined Pharmaceutical Intermediate Receiver Tank |
| Available Volume | 50L / 100L / 200L / 500L / 1000L / 2000L |
| Outer Shell Material | Mirror polished 316 stainless steel |
| Lining Material | Low-ion import PTFE sheet, lining thickness 3mm |
| Surface Roughness Inner Wall | Ra ≤0.3μm mirror polishing (GMP standard) |
| Working Temperature | -120℃ ~ 160℃ (suitable for steam sterilization) |
| Allowable Pressure | Atmospheric / -0.08MPa mild vacuum |
| Standard Sanitary Nozzles | Sanitary feed port, sterile sampling port, quick-release discharge port, vacuum port |
| Connection Standard | Sanitary clamp flange (no thread dead angle) |
| Factory Inspection Standard | Cleanliness test + 10KV full wall spark leakage test |
1. Core Material Working Principle
The tank adopts dual-layer isolation anti-pollution structure:
• Outer shell: Polished 316 stainless steel pressure shell, stable mechanical structure, easy external alcohol disinfection, no rust contamination risk in clean room environment;
• Inner barrier: Imported ultra-pure sodium activated PTFE sheet via integral vacuum lamination. The molecular structure of PTFE is chemically inert, helps minimize contact between the process medium and the metal substrate, reducing the risk of metal ion contaminations; all inner welds are mirror polished to eliminate residual dead corners, avoid cross-contamination of different drug batches. Smooth PTFE lining surface reduces intermediate adhesion, facilitates hot water & steam circulation sterilization between batches.
• API Vacuum Rectification Process: Collect low-temperature condensed high-purity pharmaceutical distillate under continuous negative pressure;
• Medical Intermediate Crystallization Process: Buffer and store crystallized drug slurry after cooling reaction;
• Biochemical Reagent Synthesis: Receive neutral & weakly corrosive biological reaction intermediates;
• Multi-Batch Purification Separation: Temporary transfer of finished intermediate before filtration & drying;
• GMP Closed Clean Line: Full sealed docking with PTFE lined pharmaceutical reactor & purification column to rhelp reduce exposure to external contaminants through closed transfer.
· Based on Batch Production Volume Small lab pilot synthesis: Choose 50L–200L mini receiver tank; formal mass pharmaceutical production line: select 500L–2000L medium sanitary model.
· According To Intermediate Properties Weakly corrosive organic drug intermediates: Standard 3mm low-ion PTFE lining; fluorine-containing medical raw materials: customized thickened anti-fluoride lining.
· Matching Vacuum Distillation Equipment Long-time vacuum purification process: Reinforce vacuum bonding lining process, avoid lining separation under negative pressure.
· Clean Room Layout Matching Compact small clean workshop: Vertical narrow-body design; multi-unit parallel production line: customized side-mounted quick discharge nozzle.
· Sterilization Demand Matching Frequent high-temperature steam sterilization: Optimize inner rounded corner lining to prevent thermal expansion crevice residue.
| Comparison Item | Our PTFE Lined Pharmaceutical Intermediate Receiver Tank | Glass Lined Receiving Vessel | Ordinary PFA Sprayed Tank | Industrial General Lined Receiver |
| Ion Precipitation | Ultra-low metal ion release, meet GMP | Easy glass fragment falling | Thin coating easy scratch pollution | High impurity precipitation |
| Sterilization Adaptability | Full steam sterilization available | Limited temp resistance | Coating aging after repeated sterilization | Not fit clean disinfection |
| Dead Angle Design | All rounded corner no residue | Sharp corner drug accumulation | Many welding dead corners | Industrial right-angle structure |
| Vacuum Stability | Stable long-time distillation vacuum | Fragile under negative pressure | Coating peeling risk | Easy lining bubbling |
| Application Scene | GMP pharmaceutical clean workshop | Lab small test only | Non-high-purity chemical use | Industrial acid production line |
| Service Life | 8–12 years | 3–5 years | 4–6 years | 7–10 years |
1. Professional GMP-oriented lining production workshop, independent dust-free lining area separated from industrial equipment production, avoid cross contamination during processing.
2. Adopt medical grade imported PTFE raw material, provide raw material purity test report for pharmaceutical factory audit documents.
3. Full mirror inner polishing process for all tank bodies, professional technical team optimizes nozzle layout according to clean room drawing.
4. Complete pharmaceutical supporting matching capacity: Can supply lined pharmaceutical reactor & purification column as one set closed production line.
5. Strict dual inspection standard (cleanliness + spark test) before delivery, supply full batch inspection files for drug factory record filing.
6. Multilingual pharmaceutical technical support, provide free intermediate compatibility analysis, remote installation guidance for clean room equipment.
7. Custom sanitary spare parts long-term supply, 5-year special anti-contamination lining global warranty.
A: Yes, the inner lining is low-ion medical PTFE with mirror rounded polishing, we can provide complete cleanliness inspection documents for factory audit.
A: The PTFE lining adapts circulating steam sterilization within 160℃, no medium residue adhesion after cleaning.
A: We can customize thickened anti-fluoride PTFE lining for fluorinated medical raw material working conditions.
A： All feeding, sampling and discharge ports adopt sanitary clamp flange without threaded dead angles, fully customizable layout.
A： Stable long-term operation under -0.08MPa vacuum environment, no lining bubbling or peeling.
A： We provide one-stop supporting of reactor, purification column and receiver tank for complete pharmaceutical production line.
Address
80 Min’an Road, High-tech Zone, Zibo City, Shandong Province, China
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